Premarin

Premarin is an estrogen replacement therapy (ERT) drug manufactured by Wyeth Pharmaceuticals. Premarin is prescribed to women to reduce common symptoms of menopause or hysterectomy such as hot flashes and vaginal dryness.

Until the late 1970's, Premarin, Wyeth's blockbuster estrogen-only hormone replacement drug was the "cure" of choice for menopause and its dreaded effects. At its peak, Premarin generated approximately 30 million prescriptions annually. However, beginning in 1976, scientific studies demonstrated that estrogen-only therapy was associated with an increased risk of uterine (endometrial) cancer among women who used such drugs.

Data from edipemiological studies have suggested an association between the use of estrogen-only hormone replacement therapy and an ioncreased risk of ovarian cancer, particularly endometroid or clear cell epithelial ovarian cancer and serious tumors.

A study published in the British Journal of Cancer in 1999 demonstrated that the risk of developing ovarian cancer was 2.56 times greater for women who had used estrogen-only hormone replacement therapy, provided by drugs such as Premarin.

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